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These compounds not only reduce oxidative damage but also modulate inflammatory pathways, thereby providing a dual mechanism of action that is beneficial for DN treatment

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[DOI] [PubMed] [Google Scholar] 254.Tada S, et al

However, CagriBB has equivalent potency to Cagri, in CRE-reporter assays in mammalian cells expressing AMY 3 Rs (Supplementary Table 4), suggesting there is negligible impact of this rotamer difference